Dolutegravir (DTG)

Dolutegravir is a groundbreaking medication that has transformed the landscape of HIV treatment. As a powerful antiretroviral drug, it has played a pivotal role in improving the lives of people living with HIV/AIDS. In this article, we will delve into what Dolutegravir is, how it works, its uses, potential side effects, and its significant impact on the fight against HIV.

Prescription Required


Dolutegravir (Available in 10mg, 25mg, 50mg)

Therapeutic ClassAntiretroviral (Integrase Inhibitors)
DosagesDirected To The Physician
UsesHIV-1 infection treatment in combination with Other HIV medicines.
Side effects

Fatigue, GI disorders, Headache, Hepatitis, Increased level of creatinine kinase, Increased level of lipase, Insomnia, Itching, Muscle inflammation, Nausea, Renal impairment, hyperglycemia, Increased ALT and AST, Increased level of bilirubin, cholesterol, and triglycerides

Habit FormingNo Habit Forming
StorageStore below 30°C
WarningsSometimes patients miss a dose of their medicine, so the patient should take the missed dose as soon as possible. But if it is time for the next dose, skip the missed dose and take your regular dose but do not double the dose. This could be dangerous.
DisclaimerIn compliance with the Drugs and Cosmetics Act, 1940, and Drugs and Cosmetics Rules, 1945, the website doesn’t process any requests for Schedule X and other habit forming drugs.

Information ProviderDC Srivastava (B.Pharm) Pharmacist India

What is Dolutegravir?

Dolutegravir is an antiretroviral medication belonging to the class of drugs known as integrase strand transfer inhibitors (INSTIs). It is specifically designed to combat the Human Immunodeficiency Virus (HIV), which can lead to Acquired Immunodeficiency Syndrome (AIDS) if left untreated. Dolutegravir is available under various brand names and has become a key component of HIV treatment regimens.

How Does Dolutegravir Work?

Dolutegravir works by targeting a specific enzyme in the HIV replication process called integrase. Integrase is responsible for incorporating the virus’s genetic material into the DNA of the host cell. By inhibiting integrase, Dolutegravir prevents HIV from replicating and spreading throughout the body. This interruption in the viral life cycle helps control the infection and reduces the viral load in the patient’s bloodstream.

Uses of Dolutegravir

  1. HIV Treatment: Dolutegravir is a central component of Highly Active Antiretroviral Therapy (HAART) or antiretroviral therapy (ART) for individuals diagnosed with HIV. It is often prescribed in combination with other antiretroviral drugs to suppress the virus, enhance the immune system, and maintain a low viral load.

  2. HIV Pre-Exposure Prophylaxis (PrEP): Dolutegravir, when used as part of a PrEP regimen, can help prevent HIV infection in individuals at high risk. PrEP involves taking medication before potential exposure to HIV to reduce the risk of transmission.

Administering Dolutegravir

Dolutegravir is available in various forms, including tablets and oral suspension. The specific dosing regimen may vary depending on individual factors, such as the patient’s age, weight, and overall health. It is crucial to follow the healthcare provider’s prescription carefully and take the medication consistently for optimal results.

Potential Side Effects

While Dolutegravir is highly effective, it can have side effects, although not everyone will experience them. Common side effects may include headache, diarrhea, and nausea. 

Serious side effects are rare but can include severe allergic reactions, liver problems, and changes in body fat distribution. It is essential to report any unusual or severe symptoms to a healthcare provider promptly.

Precautions and Considerations

  • Dolutegravir should be taken as part of a comprehensive HIV treatment plan prescribed by a healthcare provider.

  • It is essential to inform your healthcare provider of all medications you are taking to prevent potential interactions.

  • Dolutegravir is not a cure for HIV. It helps manage the virus and should be taken continuously as prescribed.


Dolutegravir has revolutionized HIV treatment by providing an effective and well-tolerated option for both newly diagnosed and long-term HIV-positive individuals. Its ability to inhibit HIV replication has significantly improved the quality of life for many people living with HIV/AIDS.

Create Health Post