Beta-blockers are used mainly in the treatment of angina pectoris, cardiovascular disorders, glaucoma, heart failure, hypertension, hyperthyroidism, management of anxiety, migraine headache, tachydysrhythmias, tremor, and various other disorders. But Overdose of this medication causes Beta-blocker toxicity such as Labetalol and Carvedilol have significant alpha 1 receptor blocking effects which enhance hypotension. Carteolol and Propranolol slow conduction by blocking sodium channels (wide QRS complex). Carvedilol and Propranolol have high lipid solubility which increases CNS toxicity (CNS depression and seizures). Sotalol blocks the potassium channels which delays repolarization (prolongs QT interval).