Tenofovir Alafenamide (Tenofovir AF)

Prescription Required

CompositionTenofovir Alafenamide 
Therapeutic ClassNucleoside reverse transcriptase inhibitors (NRTIs)
Dosages Directed To The Physician
UsesChronic hepatitis B virus (HBV) infection
Side effects

Chills, Dizziness, Fatigue, Fever, Headache, Nasal infection, Nausea, Otitis media, Skin rash, Throat infection, Vomiting

Habit FormingNo Habit Forming
StorageStore below 30°C
WarningsSometimes patients miss a dose of their medicine, so the patient should take the missed dose as soon as possible. But if it is time for the next dose, skip the missed dose and take your regular dose but do not double the dose. This could be dangerous.
DisclaimerIn compliance with the Drugs and Cosmetics Act, 1940, and Drugs and Cosmetics Rules, 1945, the website Pharmacyhelp.in doesn’t process any requests for Schedule X and other habit forming drugs.

Information ProviderDC Srivastava (B.Pharm) Pharmacist India

Tenofovir Alafenamide: Uses, Dosage, Side Effects, Interactions

In the landscape of HIV/AIDS treatment, Tenofovir Alafenamide (TAF) has emerged as a pivotal medication that has transformed the lives of individuals living with the virus. This comprehensive guide provides insights into the uses, dosage, potential side effects, and interactions associated with Tenofovir Alafenamide.

Uses of Tenofovir Alafenamide

Tenofovir Alafenamide is a potent antiretroviral medication indicated for the treatment of human immunodeficiency virus (HIV) infection. When used as part of a combination antiretroviral therapy regimen, Tenofovir Alafenamide plays a critical role in suppressing viral replication, improving immune function, and enhancing overall health in individuals with HIV/AIDS. It is a cornerstone of modern antiretroviral treatment strategies.

Dosage and Administration

Dosage Forms: Tenofovir Alafenamide is commonly available in tablet form with varying strengths, including 25 mg, 10 mg, and 40 mg.

Dosage Recommendations: The recommended adult dosage of Tenofovir Alafenamide varies based on the specific combination regimen and the individual’s medical history. It’s crucial to follow the prescribed dosage provided by a healthcare professional.

Administration: Tenofovir Alafenamide tablets can generally be taken with or without food. However, following specific dosing instructions provided by the healthcare provider is essential for optimal effectiveness.

Potential Side Effects

Tenofovir Alafenamide is generally well-tolerated, but there are potential side effects that individuals should be aware of. Common side effects may include:

  • Nausea
  • Diarrhea
  • Headache
  • Fatigue
  • Changes in body fat distribution

Kidney and Bone Health

One significant advantage of Tenofovir Alafenamide is its potential to cause fewer kidney and bone-related side effects compared to its predecessor, Tenofovir Disoproxil Fumarate (TDF). This makes Tenofovir Alafenamide a preferred choice for individuals who may be at risk for kidney or bone issues.

Precautions and Considerations

  • Medical Supervision: Tenofovir Alafenamide should be used under the supervision of a qualified healthcare professional experienced in HIV/AIDS treatment.
  • Adherence: Adhering to the prescribed dosage and regimen is essential for effective viral suppression and to prevent the development of drug-resistant strains of HIV.
  • Regular Monitoring: Regular medical follow-ups, including viral load and CD4 cell count assessments, are crucial to monitor treatment progress and adjust the regimen if necessary.

Drug Interactions

Combination Regimens: Tenofovir Alafenamide is often used in combination with other antiretroviral medications. It’s vital to be aware of potential drug interactions and to communicate all medications being taken to healthcare providers.

Alcohol and Substance Use: Alcohol and certain substances can interact with Tenofovir Alafenamide and impact its effectiveness. Discuss alcohol and substance use with a healthcare professional.


Tenofovir Alafenamide has significantly contributed to advancing the treatment landscape for individuals with HIV/AIDS. By understanding its uses, dosage, potential side effects, and interactions, individuals can make informed decisions about their healthcare journey. Collaborating closely with healthcare professionals and adhering to treatment regimens empowers individuals to effectively manage their condition and improve their quality of life.

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