Zerodol SP: Composition, Uses, Indications, Side Effects, And Price

Zerodol SP tablet is a versatile and potent medication that offers a combination of aceclofenac, paracetamol, and serratiopeptidase. This unique composition enables Zerodol SP to effectively address inflammation, swelling, and pain arising from various health conditions. In this comprehensive guide, we delve into the composition, uses, indications, potential side effects, and price of Zerodol SP.

Zerodol SP Tablet Composition

Zerodol SP tablet is formulated by Ipca Laboratories Limited and consists of three key components:

  • Aceclofenac  1oo Mg: This non-steroidal anti-inflammatory drug (NSAID) works by inhibiting cyclooxygenase enzymes, which are responsible for producing pain-inducing prostaglandins. By reducing inflammation and swelling, aceclofenac provides relief from discomfort.

  • Paracetamol 325 Mg: Renowned for its analgesic and antipyretic properties, paracetamol acts as a pain reliever by blocking pain impulses and influencing the body’s temperature regulation center. It effectively alleviates pain and fever-related discomfort.

  • Serratiopeptidase 15 Mg: As a proteolytic enzyme, serratiopeptidase contributes to reducing inflammation, pain, and swelling. It aids in accelerating the healing process by breaking down dead tissue and facilitating tissue recovery.

 Zerodol SP Tablet Uses And Indications

Zerodol SP tablet finds uses in a range of health conditions, including:

  • Mild to Moderate Visceral Pains: Zerodol SP efficiently alleviates various visceral pains caused by injuries, infections, surgeries, and other sources. Its anti-inflammatory properties play a crucial role in pain management.

  • Faster Healing: Beyond pain relief, Zerodol SP contributes to a faster recovery process, promoting overall healing. The inclusion of serratiopeptidase aids in tissue recovery and regeneration.

  • Inflammation and Swelling: Zerodol SP’s anti-inflammatory effects make it a valuable asset in managing swelling and inflammation associated with diverse health issues.

  • Fever Conditions: The antipyretic effects of paracetamol provide relief from fever-related discomfort, making Zerodol SP a versatile choice.

Zerodol SP Tablet Side Effects

While Zerodol SP is generally safe, it’s important to be aware of potential side effects, which can vary based on the individual’s response to the medication. Some possible side effects include:

  • Aceclofenac: Common side effects may include dyspepsia, abdominal pain, nausea, diarrhea, dizziness, and increased hepatic enzyme levels. Rare side effects encompass granulocytopenia, thrombocytopenia, and depression.

  • Paracetamol: Rare side effects of paracetamol include blood dyscrasias, thrombocytopenic purpura, and methemoglobinemia.

  • Serratiopeptidase: Possible side effects involve rash, hypersensitivity, muscle and joint pain, and gastrointestinal discomfort.

Zerodol-SP Dosage: Finding the Right Balance for Relief

Zerodol-SP is a versatile medication that combines aceclofenac, paracetamol, and serratiopeptidase to effectively manage pain, inflammation, and swelling. As with any medication, getting the dosage right is crucial for optimal results and safety. Here’s a detailed overview of Zerodol-SP dosage guidelines:

Dosage Forms and Strengths:

Zerodol-SP is available in tablet form, with each film-coated tablet containing the following active ingredients:

  • Aceclofenac IP 100 mg
  • Paracetamol IP 325 mg
  • Serratiopeptidase IP 15 mg (as enteric-coated granules equivalent to enzyme activity of 30,000 Units) Excipients are also present to ensure proper formulation.

Zerodol-SP Dosage for Adults:

For adults seeking relief from pain and inflammation, the recommended dosage is as follows:

  • Take One tablet of Zerodol-SP twice daily.

It’s important to adhere to this dosage and not exceed the recommended frequency. If you find that your symptoms persist despite following the recommended dosage, consult your healthcare provider before making any adjustments.

Zerodol-SP Dosage for Geriatrics:

Elderly patients with normal renal and hepatic (liver) functions can generally follow the same dosage instructions as adults. However, a cautious approach is advised, and it’s recommended to consult with a physician before starting the medication. As individual health conditions and needs can vary among geriatric patients, personalized guidance ensures that the medication is safe and effective.

Note on Pediatric Use:

As of now, there is no established dosing data for pediatric patients. This means that Zerodol-SP is not recommended for use in children until specific dosing guidelines are determined based on thorough clinical research and assessment. If your child requires pain or inflammation management, consult a pediatrician to explore suitable alternatives.

Administration Tips:

To ensure the best results and minimize the risk of side effects, keep these administration tips in mind:

  • Take Zerodol-SP tablets approximately two hours after a meal.
  • Swallow the tablet with a glass of water. Do not crush or chew the tablet.
  • Adhere to the prescribed dosage schedule for consistent relief.
  • If you accidentally miss a dose, take it as soon as you remember. If it’s close to the time for the next dose, skip the missed dose and continue with the regular schedule.

Mechanism of Action

Understanding how each component of Zerodol SP works helps comprehend its mechanism of action:

  • Aceclofenac: By inhibiting cyclooxygenase enzymes, aceclofenac reduces the production of pain-inducing prostaglandins, providing analgesic and anti-inflammatory effects.

  • Paracetamol: Paracetamol acts as an analgesic by inhibiting pain impulses and an antipyretic by influencing the body’s temperature regulation center.

  • Serratiopeptidase: This proteolytic enzyme contributes to reducing inflammation, pain, and swelling by breaking down inflammatory mediators. It aids in accelerating tissue recovery.

Zerodol SP Contraindications: When to Avoid Its Use

Zerodol SP tablet, although effective for many, comes with specific contraindications that need to be taken into consideration before its use. Understanding these contraindications is crucial to ensure the safe and effective use of the medication. Here are the scenarios in which Zerodol-SP should be avoided:

  1. Known Hypersensitivity: If you have a known hypersensitivity or allergy to aceclofenac, paracetamol, serratiopeptidase, or any other component present in the formulation, it’s best to avoid using Zerodol-SP. Because allergic reactions can range from mild skin rashes to severe anaphylactic reactions.

  2. Peptic Ulcer and Bleeding History: If you have an active or history of recurrent peptic ulcers, bleeding disorders, or a history of gastrointestinal (GI) bleeding or perforation (hole in the GI mucosa) due to previous NSAID therapy, Zerodol-SP should be avoided. The medication can exacerbate these conditions and lead to complications.

  3. Severe Heart, Liver, and Kidney Conditions: Zerodol-SP is contraindicated in individuals with severe heart failure, hepatic (liver) failure, and renal (kidney) failure. The medication can potentially worsen these conditions and have detrimental effects on organ function.

  4. Congestive Heart Failure and Cardiovascular Issues: Patients with confirmed congestive heart failure (NYHA class II-IV), peripheral arterial disease, ischaemic heart disease, and cerebrovascular disease should steer clear of Zerodol-SP. The medication can pose risks to the cardiovascular system and worsen existing conditions.

  5. Last Trimester of Pregnancy: Zerodol-SP should not be used during the last trimester (last three months) of pregnancy. It can produce adverse effects on both the mother and the developing fetus. Consult a healthcare professional for suitable alternatives during pregnancy.

  6. Aspirin or NSAID Allergies: If you have a history of asthma, urticaria (skin rash), or acute rhinitis (runny or watery nose) precipitated by aspirin or other non-steroidal anti-inflammatory drugs (NSAID’s), using Zerodol-SP is not recommended. Such individuals are at an increased risk of developing allergic reactions.

  7. Acute Porphyria: Zerodol-SP should be avoided in cases of acute porphyria, a condition characterized by the build-up of natural chemicals called porphyrins. The medication can potentially worsen the symptoms and complications associated with this condition.

Zerodol-SP Drug Interactions: Understanding Potential Risks

When it comes to medications, interactions between different drugs, food, or supplements can lead to unexpected and undesired effects. Zerodol-SP, a medication with a combination of active ingredients, is no exception. Understanding the potential drug interactions of Zerodol-SP is crucial to ensure your safety and the effectiveness of your treatment plan. Let’s delve into the interactions associated with Zerodol-SP:

Aceclofenac Interactions:

+ Lithium: Aceclofenac, like many NSAIDs, has the potential to increase the plasma concentration of lithium, which can lead to hazardous effects. Monitoring lithium levels is important when taking Zerodol-SP alongside lithium.

+ Digoxin: NSAIDs, including aceclofenac, can impact the kidneys and worsen heart failure. They may also raise plasma levels of cardiac glycosides like digoxin, potentially lowering the glomerular filtration rate (GFR) in individuals taking cardiac glycosides.

+ Diuretics: Aceclofenac, similar to other NSAIDs, might interfere with the effectiveness of diuretics. While interactions with specific diuretics like bendrofluazide are less likely to impact blood pressure regulation, monitoring serum potassium levels is crucial when using potassium-sparing diuretics concurrently.

+ Anticoagulants (Blood Thinners): Aceclofenac can enhance the blood-thinning activity of anticoagulants, leading to an increased risk of bleeding. Close monitoring is essential when using both medications together.

+ Methotrexate: Taking NSAIDs and methotrexate within 24 hours of each other may elevate plasma levels and increase toxicity. Caution is advised when these medications are used in close proximity.

+ Mifepristone: Following mifepristone administration, NSAIDs should be avoided for 8 to 12 days, as they can reduce the effectiveness of mifepristone.

+ Corticosteroids: Concurrent use of aceclofenac and corticosteroids can elevate the risk of gastrointestinal bleeding or ulcers.

+ Anti-platelet Agents and SSRIs: Combining aceclofenac with antiplatelet agents or selective serotonin reuptake inhibitors (SSRIs) may heighten the risk of gastrointestinal bleeding.

+ Cyclosporine: NSAIDs’ impact on renal prostaglandins might make cyclosporine more toxic to the kidneys.

+ Quinolone Antimicrobials: Quinolones and NSAIDs may interact, potentially resulting in convulsions. This interaction could occur in patients with or without a history of convulsions.

Paracetamol Interactions:

+ Cholestyramine: Cholestyramine can slow down the absorption rate of paracetamol. If maximum pain relief is necessary, avoid administering cholestyramine within an hour of taking paracetamol.

+ Domperidone with Metoclopramide: The absorption of paracetamol can be enhanced when used alongside domperidone and metoclopramide.

+ Warfarin and Coumarins: Prolonged or frequent use of paracetamol can heighten the anticoagulant effect of warfarin and other coumarins, increasing the risk of bleeding. Intermittent doses have minimal or no effect.

+ Chloramphenicol: Combining paracetamol and chloramphenicol can significantly slow down the elimination of paracetamol, potentially leading to increased plasma concentrations and adverse effects.

+ Isoniazid, Alcohol, and Anticonvulsants: The administration of these substances alongside paracetamol can elevate the risk of liver toxicity.

Serratiopeptidase Interactions:

+ Anticoagulant/Antiplatelet Drugs: Combining serratiopeptidase with aspirin, warfarin, or clopidogrel can increase the risk of bleeding or bruising.

+ Natural Substances: Serratiopeptidase may enhance the risk of bleeding or bruising when used in conjunction with natural substances like turmeric, fish oil, and garlic.

Understanding these interactions is vital to ensure your safety and well-being while using Zerodol-SP. Always consult your healthcare provider before combining any medications, and inform them about your medical history, existing conditions, and other medications you are taking. Your healthcare provider can guide you in making informed decisions about your treatment plan.

Zerodol SP Tablet Price

Maximum retail price as per year 2023: ₹ 118.30

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